Human ERN1 / IRE1 Protein (aa 465-977, His & GST Tag) 11905-H20B from Sino Biological, Inc.

Product Specs
ItemHuman ERN1 / IRE1 Protein (aa 465-977, His & GST Tag)
CompanySino Biological, Inc.
Price Supplier Page View Company Product Page
Catalog Number11905-H20B
Conjugate/TagN-GST, His
Purity≥ 80 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human ERN1/GST chimera consists of 750 amino acids and has a calculated molecular mass of 86 kDa. It migrates as an approximately 90 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameERN1
Source/Expression SystemBaculovirus-Insect Cells
ActivityThe specific activity was determined to be 5 nmol/min/mg using MBP as substrate
FormatSupplied as sterile 20mM Tris, 500M NaCl, 25% glycerol, 0.1mM EDTA, 0.5mM TCEP, 2mM GSH, pH 7.5
NCBI Full Gene Nameendoplasmic reticulum to nucleus signaling 1
NCBI Gene AliasesIRE1, IRE1P, IRE1a, hIRE1p

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Sino Biological, Inc.

1400 Liberty Ridge Drive

Suite 101

Wayne, PA 19087

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: http://www.sinobiological.com/

(1) A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatmentiScienceMay 19, 2023Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Timothy Langlais, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, et al.poly-histidine-tag and GST tag was purchased from Sinobiological (Sino Biological Europe GmbH, Eschborn, Germany, #11905-H20B). The fluorescent probe used for the in vitro IRE1 RNase assay was from Eurogentec (Cy3-CAUGUCCGCAGCGCAUG-BHQ3).

(2) Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibitionActa pharmacologica SinicaJanuary 1, 2023Jiang KL, Liu CM, Nie LT, Jiang HN, Xu L, Zhang KZ, Fan LX, Gao AH, Lin LL, Wang XY, et al.

(3) Structure-Based Drug Discovery of IRE1 ModulatorsMethods in molecular biology (Clifton, N.J.)January 1, 2022Pelizzari Raymundo D, Eriksson LA, Chevet E, Guillory X.

(4) Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1 activityThe FEBS journalFebruary 1, 2021Doultsinos D, Carlesso A, Chintha C, Paton JC, Paton AW, Samali A, Chevet E, Eriksson LA.

(5) Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathwayThe Journal of biological chemistryOctober 31, 2014Zhu X, Zhang J, Sun H, Jiang C, Dong Y, Shan Q, Su S, Xie Y, Xu N, Lou X, et al.

(6) A synthetic biology approach identifies the mammalian UPR RNA ligase RtcBMolecular cellSeptember 4, 2014Lu Y, Liang FX, Wang X.

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Human ERN1 / IRE1 Protein (aa 465-977, His & GST Tag)

Human ERN1 / IRE1 Protein (aa 465-977, His & GST Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

Citations (6)

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Human ERN1 / IRE1 Protein (aa 465-977, His & GST Tag) from Sino Biological, Inc.

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